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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are typically described as focusing on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for practical trials to be valid and also helps to reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.
Pragmatic Play is also a major player in the live casino market, offering an array of classic table games such as Blackjack and Roulette in various variations. The live studios of Pragmatic Play's offices in Romania and
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Pragmatic Play is a relatively new player in the online casino industry, but it has made a name for itself with its mobile-friendly slots. Their games are optimized for mobile phones, and run using HTML5 technology. They are also certified by trusted gaming authorities to ensure fairness and transparency. This is a good indication for players as it implies that the games are checked and verified to ensure that the outcomes of each round are random and unbiased.
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The majority of Pragmatic Play games are available for free, so you can test them before deciding to play for real money. These games are made to play on all kinds of devices, from desktops to tablets and smartphones. You can play them wherever you're connected to the internet. They are simple to navigate. Some Pragmatic Play sites even allow players to test their skills on the go using the practice mode. This will help you become familiar with the game rules and features prior to playing with real money.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to determine the cause-effect relationship of an intervention and its effects. They should, however, not be used to replace the need for explanation studies.
The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial, including the recruitment process, the design and delivery of the intervention, as well as follow-up.
There is a positive increase in the number pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatism. It is important to remember that the majority were conducted in primary-care settings.
