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Pragmatic trials are trials designed to inform real-world clinical practice. They are typically characterized by a focus on the practical aspects of study design, such as recruitment and consent, adherence, and the use of routinely available equipment.
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The developer is famous for its stunningly beautiful slots that captivate players with their vibrant colors and captivating designs. They employ advanced graphics to create a thrilling gameplay that lets players experience an adventure. Their games are tested for fairness and rely on the Random Number Generator to ensure random outcomes. Additionally, their mobile-friendly design makes them ideal for players who are on the move.
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While Pragmatic Play is known for its slot machines, it also provides table games such as Bitcoin baccarat and Roulette. They offer more than a dozen licensed titles, and their software is well-known for its security and reliability. Their products are available across multiple languages and include several betting options, including live dealer tables.
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Pragmatic is a software company offers a range of casino games for online gambling platforms. Pragmatic's iGaming software is used by leading operators and land based casinos. The company offers front-end site design tools, analysis and marketing, promotions security payment systems, customer support, and bug reporting. In addition, the company provides its players a secure environment with high-quality graphics as well as gameplay.
The company has a large library of games that are available for demo play. It lets players try out new titles without logging in or registering. These games are played instantly, and they offer a real casino feel. They are accessible on mobile devices, desktops and tablets.
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Gates of Olympus, a new release by the company, transports players into the realm of the ancient Greek Gods where Zeus oversees all the action. This high-volatility game features a Pay Anywhere feature that rewards players with wins when they land eight or more identical symbols anywhere on the reels. This game also comes with the Free Spins bonus with multipliers up to 500x your bet.
A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for practical trials to be valid and reduces bias in the results. However excessive heterogeneity could result in problems with the design of the trial.
Pragmatic Play is also a major player on the live casino market, providing a wide selection of table games that are classic such as Blackjack and Roulette in various variations. The company's live studios in Romania and Malta offer a real-life gaming experience for its customers and offer an extensive selection of virtual betting options. The company also has several games that make online gambling fun and interactive. Some of these shows are hosted live and others feature famous personalities in the industry.
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Pragmatic Play is a new player in the online casino market however, it has earned a name with its mobile-friendly slots. Their games are optimised for mobile devices and run on HTML5 technology. They are also regulated and certified by trusted gaming authorities, ensuring fairness and transparency. This is a positive sign for players as it indicates that the games have been tested and validated to ensure randomness and unbiased results of every round.
Pragmatic Play offers not only mobile-friendly slot machines but also live casino and table games. The company is licensed and is regulated by various governing bodies that include the Malta Gaming Authority and UK Gambling Commission. Its games are backed by high-end encryption and the security team is always available to assist players with any issues they might have.
Pragmatic Play's slot games are very popular with newbies as well as experienced players. They feature modern graphics as well as traditional themes. Many of them have progressive jackpots as well as numerous bonus rounds and paylines. They are also not very volatile and you can expect to have a long-lasting gaming session with them.
Most of the Pragmatic Play games are available for free, which means you can play them before deciding to play them with real money. These games can be played on any device including tablets, desktops and even smartphones. They're easy to navigate and you can play from anywhere with an internet connection. Some Pragmatic Play websites even let you test your luck moving around by playing a test mode. This can help you become familiar with the game rules and features before playing for real money.
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Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. Its software is accessible on mobile devices and in a variety of languages. It has been recognized as one of the leading gaming platforms for casinos despite its relatively young age. Its latest releases include Wolves, a 5-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They are also a good method of determining the causality between an intervention and its outcomes. However, they should not be used as a substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a pragmatic study that include the recruitment process, the design and implementation of the intervention, and the follow-up.
There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.
