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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often described as a focus on the practical aspects of design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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A practical trial that employs a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results is also essential. However, too much heterogeneity can lead to problems with the design of the trial.
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Pragmatic Play has gained a reputation for offering high-quality games and a superior user experience. Its software is accessible on mobile devices and in multiple languages. It has earned itself the status of one of the most popular casino gaming platforms despite its relative youth. Wolves is one of the latest games that is a 5-reel slot machine with a hefty RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are usually requested by practitioners and policymakers in order to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used as a substitute for the use of explanation trials.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic study which includes the recruitment process, the design and
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check it out, implementation of the intervention, and the follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary-care settings.
