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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of the research design, like the recruitment process and consent, adherence, and the use of standard equipment.
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A pragmatic trial that uses a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be able to prove their validity and also helps to reduce the chance of bias in the results. Too much heterogeneity, however could cause issues with the trial design.
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Legality
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The goal of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. Usually, they are ordered by policymakers and practitioners in order to inform their decisions. They also provide a useful way to identify the causality between an intervention and its outcomes. However, they should not be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested the framework for
프라그마틱 무료 슬롯 pragmatic trials, called PRECIS.2 This tool sought to define the features of a practical trial that include recruitment, design and delivery of the intervention, as well as the follow-up.
The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.
