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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, including the recruitment process and consent, adherence, and the use of standard equipment.
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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid and helps to reduce the chance of bias in the results. However excessive heterogeneity could cause problems with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They are also a good way to identify the causal relationship between the intervention and its effects. However, they should not be used to replace explanation studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they are an alternative to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the practice and
프라그마틱 슬롯 추천 policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the elements of a practical study which includes recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health science community is becoming more sensitive to the issue of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary care settings.
